Egfr Mdrd Calculator

MDRD Equation:

\[ eGFR = 175 \times (Scr)^{-1.154} \times (Age)^{-0.203} \times (0.742 \text{ if female}) \times (1.212 \text{ if African American}) \]

Serum Creatinine (Scr):

mg/dL

Age:

years

Gender:

Race:

Estimated GFR (eGFR):

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1. What is the MDRD Equation?

The MDRD (Modification of Diet in Renal Disease) equation estimates glomerular filtration rate (GFR) from serum creatinine, age, sex, and race. It was developed to provide a more accurate assessment of kidney function in patients with chronic kidney disease.

2. How Does the Calculator Work?

The calculator uses the MDRD equation:

\[ eGFR = 175 \times (Scr)^{-1.154} \times (Age)^{-0.203} \times (0.742 \text{ if female}) \times (1.212 \text{ if African American}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( Age \) — Age in years
0.742 — Female multiplier
1.212 — African American race multiplier

Explanation: The equation uses a power function to model the inverse relationship between serum creatinine and GFR, with adjustments for age, gender, and race.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for diagnosing and staging chronic kidney disease, monitoring disease progression, and adjusting medication dosages for renal clearance.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, select gender and race. All values must be valid (creatinine > 0, age between 1-120).

5. Frequently Asked Questions (FAQ)

Q1: What is the difference between MDRD and CKD-EPI equations?
A: While both estimate GFR, CKD-EPI is generally more accurate at higher GFR levels (>60 mL/min/1.73m²) and is now more commonly used in clinical practice.

Q2: What are the limitations of the MDRD equation?
A: The MDRD equation may be less accurate in elderly patients, those with normal or near-normal kidney function, and in populations with extreme body sizes.

Q3: When was the MDRD equation developed?
A: The MDRD equation was developed in 1999 and subsequently re-expressed in 2005 for use with standardized creatinine measurements.

Q4: Is the MDRD equation suitable for all populations?
A: The equation was validated primarily in patients with chronic kidney disease and may be less accurate in healthy populations or those with acute kidney injury.

Q5: How often should eGFR be monitored?
A: Frequency of monitoring depends on the clinical situation, but typically eGFR is checked every 3-12 months in patients with known kidney disease.