Gfr Mdrd Calculator

MDRD Equation:

\[ eGFR = 175 \times (Scr)^{-1.154} \times (Age)^{-0.203} \times (0.742 \text{ if female}) \times (1.212 \text{ if black}) \]

Serum Creatinine (Scr):

mg/dL

Age:

years

Gender:

Race:

Estimated GFR (eGFR):

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1. What is the MDRD Equation?

The MDRD (Modification of Diet in Renal Disease) equation estimates glomerular filtration rate (GFR) from serum creatinine, age, sex, and race. It was widely used before the development of the CKD-EPI equation and remains relevant in certain clinical contexts.

2. How Does the Calculator Work?

The calculator uses the MDRD equation:

\[ eGFR = 175 \times (Scr)^{-1.154} \times (Age)^{-0.203} \times (0.742 \text{ if female}) \times (1.212 \text{ if black}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( Age \) — Age in years
0.742 — Female multiplier
1.212 — Black race multiplier

Explanation: The equation uses a power function to estimate GFR based on serum creatinine and age, with adjustment factors for gender and race.

3. Importance of eGFR Calculation

Details: GFR estimation is essential for assessing kidney function, diagnosing chronic kidney disease, determining disease stage, and guiding treatment decisions.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, select gender and race. All values must be valid (creatinine > 0, age between 1-120).

5. Frequently Asked Questions (FAQ)

Q1: What is the difference between MDRD and CKD-EPI equations?
A: The MDRD equation is less accurate at higher GFR levels (>60 mL/min/1.73m²) compared to the CKD-EPI equation, which was developed to address this limitation.

Q2: When is the MDRD equation still used?
A: Some laboratories and clinical settings continue to use the MDRD equation, particularly for consistency with historical data or in specific patient populations.

Q3: What are the limitations of the MDRD equation?
A: The equation may be less accurate in elderly patients, those with extreme body sizes, and populations not well represented in the original study.

Q4: Should I use MDRD or CKD-EPI for clinical decision making?
A: Current guidelines generally recommend using the CKD-EPI equation, but consult with your healthcare provider for guidance specific to your situation.

Q5: Can this calculator be used for drug dosing?
A: While eGFR estimates can inform drug dosing decisions, specific medications may require measured GFR or alternative estimation methods for precise dosing.