1. What is the MDRD Equation?

The MDRD (Modification of Diet in Renal Disease) equation estimates glomerular filtration rate (GFR) from serum creatinine, age, sex, and race. It was developed to provide a more accurate assessment of kidney function in patients with chronic kidney disease.

2. How Does the Calculator Work?

The calculator uses the MDRD equation:

Where:

• \( Scr \) — Serum creatinine (mg/dL)
• \( Age \) — Age in years
• \( Factors \) — Gender and race multipliers (0.742 for female, 1.212 for black)

Explanation: The equation provides an estimation of glomerular filtration rate based on serum creatinine levels, adjusted for age, gender, and race factors.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is crucial for diagnosing chronic kidney disease, determining disease stage, monitoring progression, and guiding medication dosing decisions.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, select gender and race. All values must be valid (creatinine > 0, age between 1-120).

5. Frequently Asked Questions (FAQ)

Q1: What is the difference between MDRD and CKD-EPI equations?
A: While both estimate GFR, CKD-EPI is generally more accurate at higher GFR levels (>60 mL/min/1.73m²) and is the currently preferred equation.

Q2: What are the limitations of the MDRD equation?
A: The MDRD equation may underestimate GFR in healthy individuals and is less accurate in extremes of age, body size, and certain ethnic groups.

Q3: When was the MDRD equation developed?
A: The MDRD equation was developed in 1999 and has been widely used, though newer equations like CKD-EPI are now often preferred.

Q4: Can MDRD be used for all patient populations?
A: The equation may be less accurate in pregnant women, children, elderly patients, and those with unusual muscle mass or diet.

Q5: Is fasting required for creatinine measurement?
A: While not always required, fasting samples are preferred as non-fasting levels can be affected by recent meat consumption.