1. What is the MDRD GFR Equation?

The MDRD (Modification of Diet in Renal Disease) equation estimates glomerular filtration rate (GFR) from serum creatinine, age, sex, and race. It is widely used for assessing kidney function and staging chronic kidney disease.

2. How Does the Calculator Work?

The calculator uses the MDRD equation:

Where:

• \( Scr \) — Serum creatinine (mg/dL)
• \( age \) — Age in years
• 0.742 — Female multiplier
• 1.212 — Black race multiplier

Explanation: The equation provides an estimation of glomerular filtration rate based on serum creatinine levels adjusted for age, gender, and race factors.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for diagnosing chronic kidney disease, determining disease stage, monitoring progression, and guiding appropriate treatment decisions.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, select gender and race. All values must be valid (creatinine > 0, age between 1-120 years).

5. Frequently Asked Questions (FAQ)

Q1: What is the main difference between MDRD and CKD-EPI equations?
A: While both estimate GFR, CKD-EPI is generally more accurate at higher GFR levels (>60 mL/min/1.73m²) and is now preferred in many clinical settings.

Q2: What are the limitations of the MDRD equation?
A: The MDRD equation may be less accurate in healthy individuals, elderly patients, and those with extreme body sizes or muscle mass.

Q3: When is the MDRD equation most appropriate?
A: The MDRD equation is particularly useful for patients with established chronic kidney disease and GFR values below 60 mL/min/1.73m².

Q4: How often should eGFR be monitored?
A: Frequency depends on the patient's condition, but typically eGFR is monitored every 3-12 months in patients with known kidney disease.

Q5: Can this calculator be used for children?
A: No, the MDRD equation is validated for adults only (age 18 and older). Pediatric patients require different equations for GFR estimation.